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D We do not have to wait for germ warfare to witness the devastating consequences of manipulating nature for malevolent purposes.

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Starting with a group of individuals already receptive by virtue of prior experience, and exploiting the natural processes that guide the development of the human brain, the leaders of the terrorists who carried out the September 11 attacks on the World Trade Center and the Pentagon reengineered an organ shaped by evolution to maximize survival into a biological weapon responsible for thousands of deaths. Without a resident neurobiologist, sophisticated laboratory facilities, or medical intervention, they were able to alter brain and behavior, simply by taking advantage of the fact that life experiences have physical consequences.

No one knows for certain what went on in the minds of the 19 men responsible for the atrocities of September The Interplay Between Brain and Environment Weighing about three pounds—80 percent of it water—the human brain seems too small and fragile even to contemplate the enormity of the attacks, much less to assume responsibility for them.

Yet crammed into that modest space are billion neurons, each capable of as many asindividual transactions with its neighbors.

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In those transactions lie the origins of our behavior, our ability to see and hear, move and talk, think and feel, plan and imagine, create and destroy. These changes, in turn, support a new outlook that colors the interpretation of sensory data and shapes new behavioral responses. Violence takes us by surprise, but on a neural level, it is years in the making. Everything from impulsive street crime to coldly plotted crimes against humanity emerges from the sum total of the interactions between the brain and the outside world, providing outward proof that this relationship has been characterized by hostility, disappointment, or frank trauma.

The Ordinary

The decision to kill is the result of a developmental process involving nature and nurture, and it begins with the basic will to survive. In addition to evading predators, it may face threats from members of its own species, not only to its personal safety, but also to the safety of its offspring, its territory, its social status, or its resources. Pushed beyond acceptable limits, against the wrong target, for the wrong reasons, aggression degenerates into violence, an infraction that does little to promote survival, but rather puts victim, perpetrator, and society at grave risk.

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If a passenger on a hijacked aircraft overpowers and best anti aging foundation the hijacker, we consider it an act of self-defense. Should the hijacker assault and kill the passenger, though, we call it murder. What is the difference? The hijacker who slaughters an innocent passenger, however, kills a defenseless individual who poses no real threat to him. His behavior is inappropriate, intolerable, extreme.

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The ratio between the intensity of the threat and the intensity of the response determines whether or not that response has transgressed the limits of acceptable behavior. When the perception of threat is best anti aging foundation, behavior is likely to suffer, and aggression erupts into violence.

How Experience Changes the Brain Neural adaptation allows each brain to answer fundamental questions in its own way. Questions relevant to the use of aggression—Is my environment safe?

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Are you friend or enemy? Human record keepers document their observations in words and numbers.

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The brain, on the other hand, is a chemical historian; it keeps track of the interactions between the brain and the environment in the language of chemistry, linking neurotransmission to best anti aging foundation activity and amount of proteins critical to brain function and structure. The chemical discussions between neurons, which begin when signal and receptor come together, do not stop at the surface, but continue inside the cell, transmitted by a network of interacting signaling proteins.

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In the short term, signals passed from protein to protein can make immediate adjustments to features like the release of neurotransmitters. In the long term, signals also initiate alterations in gene expression and in levels of the proteins they encode.

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Neuronal communication, therefore, includes a built-in mechanism for translating experience into changes in the physiology and anatomy of the brain. The brain circuitry underlying emotion encompasses not only subcortical structures like the amygdala, but also more highly developed areas of the cerebral cortex, particularly the frontal and cingulate cortices.


The cortex takes a second look, and adds experiential, analytical, and moral detail that reduce the risk of jumping to irrational conclusions. Case histories and the functional imaging of brain activity during a task involving moral reasoning suggest that the cortical regions associated with legjobb anti aging feszesítő krémek play a critical Svájci anti aging ajándékkosár in the acquisition and utilization of moral principles.

If the dialogue between brain and environment is basically amiable, and the moral standards entered into the cortical database encourage benevolence and disapprove of violence, the process results in a nervous system capable of acceptable behavior. Threat assessment is accurate, and while behavior toward others may not always be charitable, it respects the limits set by society.

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Negative experiences, in contrast, send a message that the world is hostile and unfair, distort threat perception, and produce a nervous system prepared for the worst. For some, every insinuating remark becomes an invitation to quarrel. On a physical level, their touchiness shows up in chronically elevated levels of cortisol and disruptions in serotonin function. Others downshift emotionally, developing a patent disregard for limits, the feelings of others, or the legitimate threat of retaliation.

Without intervention, the vicious circle between brain, behavior, and environment may spiral into violence—hostile outbursts in the case of the overly sensitive, and the cold, premeditated violence experts call antisocial in the case of the insensitive. Animal and human research reveals that a surprising array of insults can injure neurons and alter brain chemistry, emotional responses, and reactions to stress, not only in childhood, but throughout life.

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Disrupting the Cycle that Can Lead to Violence The disgruntled and the disaffected are fertile ground for ruthless ideologues, who supply them with targets to hate and reasons to hurt. Both discover an ally in a vengeful God eager for them to annihilate their enemies. Their formal training further fans anger into rage, strips them of any lingering feelings of guilt or remorse, and conditions them to kill without thinking. Disrupting the vicious circle that leads to terrorism requires changing the environmental factors that feed it.

Development and diplomacy may help to reduce the pool of frustrated, irate individuals susceptible to hate-mongers, but it is not enough.

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Unless those who preach violence temper their rhetoric, its toxicity will continue to corrupt the minds and behavior of the vulnerable.